{"id":27,"date":"2025-06-09T20:17:19","date_gmt":"2025-06-09T20:17:19","guid":{"rendered":"https:\/\/peugetlab.com\/?page_id=27"},"modified":"2026-07-23T17:33:22","modified_gmt":"2026-07-23T15:33:22","slug":"publications","status":"publish","type":"page","link":"https:\/\/peugetlab.com\/?page_id=27","title":{"rendered":"Selected publications"},"content":{"rendered":"\n
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2026<\/strong><\/h4>\n\n\n\n

Deep proteomics profiling of the cell secretome by DeepSec<\/a><\/span>. Wang X, Fragkoulis K, Wielento A, Willems S, Aschtgen MS, Kirk A, Modaresi SM, Gharibi H, Jafari M, Ritz D, Schmidt A, Vali H, Jalkanen J, Ryd\u00e9n M, Mejhert N, Lauschke VM, Borhan B, Mahmoudi M, Peuget S, Saei AA. [PREPRINT]<\/strong> Research Square 2026 Jul 21. doi: 10.21203\/rs.3.rs-10362172\/v1<\/p>\n\n\n\n

Deep learning-enabled discovery of antibiotics effective against Neisseria gonorrhoeae<\/em><\/a><\/span>. Anahtar MN, Valeri JA, Modaresi SM, Krishnan A, Donghia NM, Palace SG, Zheng EJ, Gulati A, Jorgenson A, Junaid A, Bandyopadhyay P, Luttens A, Suresh K, Edwards P, Wong F, Zhang Y, Ritz D, Gaborieau M, Loh E, Gaetani M, Aschtgen MS, Saei AA, Grad YH, Ingber DE, Collins JJ. Sci Transl Med<\/strong>. 2026 Jun 17;18(854):eads4699. doi: 10.1126\/scitranslmed.ads4699. PMID: 42308330<\/p>\n\n\n\n

Ligand-Mediated Proteome Remodeling Shapes Nanoparticle Protein Corona Composition for Deep Plasma Profiling<\/a>. Ghaffari B, Han L, Tamadon A, Alpaydin A, Yerima G, Wills N, Grumelot S, Ritz D, Schmidt A, Peuget S, Ghassemi M, Vali H, Mofrad MRK, Saei AA, Borhan B, Mahmoudi M. [PREPRINT]<\/strong> Research Square 2026 Apr 28. doi: 10.21203\/rs.3.rs-9421288\/v1<\/p>\n\n\n\n

Klebsiella pneumoniae<\/em> LPS drives stromal-mediated repression of p53 and colorectal cancer chemoresistance.<\/a> Fragkoulis K, \u0141asut-Szyszka B, V\u00e9gv\u00e1ri \u00c1, Ayona D, Saei AA, Aschtgen MS, Peuget S. Cell Death Dis<\/strong>. 2026 Apr 20;17(1):395. doi: 10.1038\/s41419-026-08756-4. PMID: 42002547<\/p>\n\n\n\n

Klebsiella pneumoniae<\/em> T6SS exacerbates gut inflammation promoting tumorigenesis<\/a>. Fragkoulis K, Uusi-M\u00e4kel\u00e4 MIE, Sanz G, Williams C, Schuppe-Koistinen I, Gustafsson UO, Engstrand L, Henriques-Normark B, Hayer J, Peuget S, Aschtgen MS. [PREPRINT]<\/strong> bioRxiv 2026 Mar 31. doi: 10.64898\/2026.03.31.715367<\/p>\n\n\n\n

2025<\/strong><\/h4>\n\n\n\n

A generative deep learning approach to de novo antibiotic design<\/a>. Krishnan A, Anahtar MN, Valeri JA, Jin W, Donghia NM, Sieben L, Luttens A, Zhang Y, Modaresi SM, Hennes A, Fromer J, Bandyopadhyay P, Chen JC, Rehman D, Desai R, Edwards P, Lach RS, Aschtgen MS, Gaborieau M, Gaetani M, Palace SG, Omori S, Khonde L, Moroz YS, Blough B, Jin C, Loh E, Grad YH, Saei AA, Coley CW, Wong F, Collins JJ. Cell<\/strong>.<\/em> 2025 Aug 7:S0092-8674(25)00855-4. doi: 10.1016\/j.cell.2025.07.033. PMID: 40816267<\/p>\n\n\n\n

Reply to ‘Heterogeneity of TP53 mutations necessitates differentiation with p53-rescue therapies’.<\/a> Peuget S, Selivanova G. Nat Rev Cancer<\/strong>. 2025 Jul;25(7):564-565. doi: 10.1038\/s41568-025-00825-8. PMID: 40379969<\/p>\n\n\n\n

2024<\/strong><\/h4>\n\n\n\n

Translating p53-based therapies for cancer into the clinic.<\/a> Peuget S, Zhou X, Selivanova G. Nat Rev Cancer<\/strong>. 2024 Mar;24(3):192-215. doi: 10.1038\/s41568-023-00658-3. PMID: 38287107<\/p>\n\n\n\n

2023<\/strong><\/h4>\n\n\n\n

Strategies to Isolate Extracellular Vesicles from Gram-Negative and Gram-Positive Bacteria.<\/a> Narciso AR, Aschtgen MS. Methods Mol Biol<\/strong>. 2023;2674:61-70. doi: 10.1007\/978-1-0716-3243-7_4. PMID: 37258960<\/p>\n\n\n\n

MDM2-PROTAC versus MDM2 Inhibitors: Beyond p53 Reactivation.<\/a> Peuget S, Selivanova G. Cancer Discov<\/strong>. 2023 May 4;13(5):1043-1045. doi: 10.1158\/2159-8290.CD-23-0229. PMID: 37139722<\/p>\n\n\n\n

2022<\/strong><\/h4>\n\n\n\n

Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization.<\/a> Aschtgen MS, Fragkoulis K, Sanz G, Normark S, Selivanova G, Henriques-Normark B, Peuget S. Oncogene<\/strong>. 2022 Apr;41(15):2173-2186. doi: 10.1038\/s41388-022-02238-5. PMID: 35197571<\/p>\n\n\n\n

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2026 Deep proteomics profiling of the cell secretome by DeepSec. Wang X, Fragkoulis K, Wielento A, Willems S, Aschtgen MS, Kirk A, Modaresi SM, Gharibi H, Jafari M, Ritz D, Schmidt A, Vali H, Jalkanen J, Ryd\u00e9n M, Mejhert N, Lauschke VM, Borhan B, Mahmoudi M, Peuget S, Saei AA. [PREPRINT] Research Square 2026 Jul […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-27","page","type-page","status-publish","hentry"],"featured_image_src":null,"_links":{"self":[{"href":"https:\/\/peugetlab.com\/index.php?rest_route=\/wp\/v2\/pages\/27","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peugetlab.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/peugetlab.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/peugetlab.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/peugetlab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=27"}],"version-history":[{"count":26,"href":"https:\/\/peugetlab.com\/index.php?rest_route=\/wp\/v2\/pages\/27\/revisions"}],"predecessor-version":[{"id":524,"href":"https:\/\/peugetlab.com\/index.php?rest_route=\/wp\/v2\/pages\/27\/revisions\/524"}],"wp:attachment":[{"href":"https:\/\/peugetlab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=27"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}